Cast Lower Resist on them, which will remove their immunity in most cases. For those who are Immune to Poison, well, that's simple.This option will often severely outspeed your own damage output in single player games. Equip your mercenary with gear that focuses on Crushing Blow and attackspeed, while keeping him alive with Life Tap and halting enemy regeneration with Poison Nova. It should also be noted that if you have an enemy that chases you, try to "Bone Prison" it around a bunch of bodies, as Poison Explosion does more damage than Poison Nova and also costs less mana to cast. If you have gear that adds quite a few points to your skills, then cast a few Bone Prisons on the boss as opposed to a minion, then follow the same process as above. Have the boss turn its attention to your minions, then cast Lower Resist followed by Poison Explosion (if possible), or Poison Nova. Two of which will depend on what gear you have. Once you have killed a bunch of enemies, you'll have the opportunity to take advantage of those bodies for Corpse Explosion or Revive.When you walk into the battlefield, get your Golem of choice (Clay Golem is widely used due to the 10,000+ life opportunity in Hell mode and its ability to slow enemies) to stand between you and your opponents while you cast Lower Resist and Poison Nova to kill them.
Using a Clay Golem is highly recommended. While you're in town, summon your Golem of choice.
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